C-Reactive Protein

The Salimetrics Research Library

Look up current saliva research on
C-Reactive Protein
and related analytes here!

C-Reactive Protein (CRP) is an acute phase protein produced in the liver. Serum CRP measurements are widely used as a bio-marker of inflammation in the body. Elevated levels of serum CRP have been tied to increased risk for heart disease, hypertension, stroke, and other conditions related to inflammation, such as diabetes and autoimmune disorders. (1,2,3,4,5,6,7,8,9) The relationship between serum and salivary levels of CRP is not well understood. Salivary CRP levels have been found to be higher in children with allergic asthma, and in pigs with respiratory viral infections. (10,11)In an unpublished study, sick people admitted to a hospital had average salivary CRP levels 25 times higher than healthy people. (12)Salivary CRP may largely reflect local inflammation in the mouth, but some serum CRP can enter saliva through gingival tissues, especially if periodontal disease is present. (13,14) Ongoing research is investigating the possibility that salivary CRP can be used to monitor inflammation in other parts of the body. (15,16,17,18,19,20) More »

References

Ridker, P.M. (2003). Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation, 107(3), 363-9.
Pearson, T.A., Mensah, G.A., Alexander, R.W., et al. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation,107(3), 499- 511.
Buffon, A., Liuzzo, G., Biasucci, L.M., et al. (1999). Preprocedural serum levels of C-reactive protein predict early complications and late restenosis after coronary angioplasty. J Am Coll Cardiol, 34(5), 1512-21.
Danesh, J., Wheeler, J.G., Hirschfield, G.M., et al. (2004). C-Reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med, 350(14), 1387-97.
Sesso, H.D., Buring J.E., Rifai, N., et al. (2003). C-Reactive protein and the risk of developing hypertension. JAMA, 290(22), 2945-51.
Blake, G.J., Rifai, N., Buring, J.E., & Ridker, P.M. (2003). Blood pressure, C-reactive protein, and risk of future cardiovascular events. Circulation, 108(24), 2993-9.
Dehghan, A., Kardys, I., de Maat, M.P., et al. (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes, 56(3), 872-8.
Pradhan, A.D., Manson, J.E., Rifai, N., et al. (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA, 286(3), 327-34.
Du Clos, T.W. Editorial: C-reactive protein as a regulator of autoimmunity and inflammation. (2003). Arthritis Rheum, 48(6), 1475-77.
Krasteva, A., Perenovska, P., Ivanova, A., et al. (2010). Alteration in salivary components of children with allergic asthma. Biotechnology Biotehnological Equipment, 24(2), 1866-69.
Gutiérrez, A.M., Martínez-Subiela, S., Soler, L., et al. (2009). Use of saliva for haptoglobin and C-reactive protein quantifications in porcine respiratory and reproductive syndrome affected pigs in field conditions. Vet Immunol Immunopathol, 132(2-4), 218-23.
Salimetrics internal data.
Giannobile, W.V., Beikler, T., Kinney, J.S., et al. (2009). Saliva as a diagnostic tool for periodontal disease: Current state and future directions. Periodontol 2000, 50, 52-64.
Higashi, Y., Goto, C., Jitsuiki, D., et al. (2008). Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients. Hypertension, 51(2), 446-53.
Miller, C.S., Foley, J.D., Bailey, A.L., et al. (2010). Current developments in salivary diagnostics. Biomark Med, 4(1), 171-89.
Floriano, P.N., Christodoulides, N., Miller, C.S., et al. (2009). Use of saliva-based nano-biochip tests for acute myodardial infarction at the point of care: A feasibility study. Clin Chem, 55(8), 1530-38.
Gómez-Laguna, J. Gutiérrez, A., Pallarés, F.J., et al. (2010). Haptoglobin and C-reactive protein as biomarkers in the serum, saliva and meat juice of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Vet J, 185(1), 83-7.
Gutiérrez, A.M., Martínez-Subiela, S., Eckersall, P.D., Cerón, J.J. (2008). C-reactive protein quantification in porcine saliva: A minimally invasive test for pig health monitoring. Vet J, 181(3), 261-5.
Tonetti, M.S., D’Aiuto, F., Nibali, L., et al. (2007). Treatment of periodontitis and endothelial function. N Engl J Med, 356(9), 911-20.
D’Aiuto, F., Ready, D., Tonetti, M.S. (2004). Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodont Res, 39(4), 236-41.

Passive Drool is a Preferred Collection Method

CRP is Location Dependent