The Salimetrics Research Library
Look up current research on
CRH
and related analytes here!
Corticotropin-Releasing Hormone
Corticotropin-releasing hormone (CRH, also known as CRF or corticoliberin) is a polypeptide molecule that acts as a hormone. It plays an important role in the body by serving to activate the stress response in the hypothalamic-pituitary-adrenal (HPA) axis. In response to stress, CRH is secreted by the paraventricular nucleus of the hypothalamus. CRH is then directly transported through the portal veins to the anterior lobe of the pituitary gland, where it causes the gland to release proopiomelanocortin (POMC)-derived peptides, including ACTH, MSH, and beta-endorphin. (1,2) ACTH travels through the general circulation to the adrenal glands, where it brings about the secretion of the stress hormone cortisol. (1) CRH is also produced in lymphocytes and other tissues such as skin, adipose tissue, and the female reproductive tissues. (3,4,5) CRH is thought to play a role in fetal growth and maturation, and in the physiology of parturition. (5,6) More »
References
- Tsigos, C., Chrousos, G.P. (2002). Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res, 53(4), 865-71.
- Laurent, V., Jaubert-Miazza, L., Desjardins, R., et al. (2004). Biosynthesis of proopiomelanocrotin-derived peptides in prohormone convertase 2 and 7b2 null mice. Endocrinology, 145(2), 519-28.)
- Seres, J., Bornstein, S.R., Seres, P., et al. (2004). Corticotropin-releasing hormone system in human adipose tissue. J Clin Endocrinol Metab, 89(2), 965-70.
- Kono, M., Nagat, H., Umemura, S., et al. (2001). In situ expression of corticotrophin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J, 15(12), 2297-99.
- Hobel, C.J., Dunkel-Schetter, C., Roesch, S.C., et al. (1999). Maternal plasma corticotrophin-releasing hormone associated with stress at 20 weeks: Gestation in pregnancies ending in preterm delivery. Am J Obstet Gynecol, 180, S257-63.
- Ellman, L.M., Schetter, C.D., Hobel, C.J., et al. (2008). Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation. Dev Psychobiol, 50(3), 232-41.
CRH Overview
| Approved Salivary Collection Devices | Serum-Saliva Correlation | Sensitivity | Sample Test Volume | Recommended Collection Volume | Special Considerations | Related Analytes |
|---|---|---|---|---|---|---|
| No | 1.4 ng/mL | 50 μL | 125 μL* | Plasma/Serum |
*In addition to the volume recommended for each analyte, we recommend collecting an additional 300 μL to allow for liquid handling loss and possible repeat tests (500 µL recommended for TNF-α and IL-1β).
