The Salimetrics Research Library
Look up current saliva research on
Epstein-Barr Virus
and related analytes here!
Epstein-Barr Virus
The Epstein-Barr virus (EBV), also called human herpesvirus-4 (HHV-4), is a virus of the herpes family, which includes herpes simplex virus 1 and 2. The oral mucosae are a major site for replication of EBV, and it is shed through saliva. Nearly all humans have been infected by EBV by the time they reach adulthood, and the virus is retained for life in a small fraction of B lymphocytes. (1,2) In addition, EBV can infect a variety of other epithelial, muscle, immune system cells. Stress and immunodeficiency are thought to trigger reactivation of the latent virus and increase oral shedding. (1) Epstein-Barr virus causes infectious mononucleosis, and it is thought to be involved in multiple sclerosis. More »
Laboratory tests for EBV are widely used in diagnosis, prognosis, prediction, and prevention of a range of diseases including autoimmune diseases and selected subtypes of lymphoma, sarcoma, and carcinoma. (1,3,4) The presence of EBV is an important tumor marker used in the clinical management of cancer patients. (1,5)
References
- Gulley, M.L., Tang, W. (2008). Laboratory assays for Epstein-Barr virus-related disease. J Mol Diag, 10(4), 279-92.
- Kalla, M. Schmeinck, A., Bergbauer, M., et al. (2010). AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. PNAS, 107(2), 850-55.
- Serafini, B., Rosicarelli, B., Franciotta, D., et al. (2007). Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med, 204 (12), 2899-912.
- Barzilai, O., Sherer, Y., Ram, M., et al. (2007). Epstein-Barr virus and cytomegalovirus in autoimmune diseases: Are they truly notorious? A preliminary report. Ann N Y Acad Sci, 1108, 567-77.
- Rezk, S.A., Weiss, L.M. (2007). Epstein-Barr virus-associated lymphoproliferative disorders. Hum Pathol, 38(9), 1293-304.
Epstein-Barr Virus Overview
| Approved Salivary Collection Devices | Serum-Saliva Correlation | Sensitivity | Sample Test Volume | Recommended Collection Volume | Special Considerations | Related Analytes |
|---|---|---|---|---|---|---|
| No | No | 25 μL | 75 μL* | No | No |
*In addition to the volume recommended for each analyte, we recommend collecting an additional 300 μL to allow for liquid handling loss and possible repeat tests (500 µl recommended for TNF-α and IL-1β).
