The Salimetrics Research Library
Look up current saliva research on
IGF-1
and related analytes here!
Serum IGF-1
Insulin-like growth factor (IGF-1) is a small protein hormone that is essential for normal growth and development. In serum, most of the IGF molecules exist in a complex with an additional binding protein and an acid-labile subunit (ALS). The liver is the principal source of circulating IGF-1, the binding proteins, and the ALS. IGF-1 is also expressed by all nonhepatic tissues, where it acts locally in paracrine or autocrine fashion. IGF-1 interacts with the IGF-1 receptor (IGF-1R), which then initiates a cascade of other molecular signals that help prevent apoptosis (preprogrammed cell death). IGF-1 therefore plays a key role in maintaining the critical balance between cell growth and cell death. (1,2,3,4) IGF-1 also participates in the regulation of immunity and inflammation, and it is used as a measure of oxidative stress. (5) More »
References
- Holzenberger, M., Dupont, J., Ducos, B., et al. (2003). IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature, 421(6919), 182-87.
- Yakar, S., Rosen, C.J., Beamer, W.G., et al. (2002). Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest, 110(6), 771-81.
- Kennedy, S.G., Wagner, A.J., Conzen, S.D., et al. (1997). The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev, 11(6), 701-13.
- Kulik, G., Klippel, A., Weber, M.J. (1997). Antiapoptotic signaling by the Insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol, 17(3), 1595-1606.
- Heemskerk, V.H., Daemen, M.A.R.C., Buurman, W.A. (1999). Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation. Cytokine Growth Factor Rev, 10(1), 5-14.
IGF-1 Overview
| Approved Salivary Collection Devices | Serum-Saliva Correlation | Sensitivity | Sample Test Volume | Recommended Collection Volume | Special Considerations | Related Analytes |
|---|---|---|---|---|---|---|
| No | 3.5 pg/mL | 10 μL | 25 μL* | Serum/Plasma |
*In addition to the volume recommended for each analyte, we recommend collecting an additional 300 μL to allow for liquid handling loss and possible repeat tests (500 µl recommended for TNF-α and IL-1β).
