The Salimetrics Research Library
Look up current saliva research on
IL-1β
and related analytes here!
Interleukin-1 Beta
Interleukin-1β (IL-1β) is one of a family of biologically active small protein molecules known as cytokines. Cytokines are produced by a number of different cell types, including macrophages, monocytes, fibroblasts, and dendritic cells. (1,2,3) IL-1β is an example of a pro-inflammatory cytokine, since it is involved in the body’s inflammatory response to acute or chronic infections, or to conditions that cause a persistent low-grade inflammatory state, such as obesity. (4,5) IL-1β is therefore frequently used as a bio-marker of inflammation. (6,7) A study with normal mouse parotid acinar cells has shown that they synthesize IL-1β and store it in secretory granules. The IL-1β is released from the granules following α- and β-adrenergic stimulation. (8) Relationships between IL-1β levels in blood and saliva are not fully understood. More »
References
- Giannobile, W.V., Beikler, T., Kinney, J.S., et al. (2009). Saliva as a diagnostic tool for periodontal disease: Current state and future directions. Periodontology 2000, 50, 52-64.
- Pirhonen, J., Sareneva, R., Kurimoto, M., et al. (1999). Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol, 162(12), 7322-29.
- Park, D.R., Thomsen, A.R., Frevert, C.W. et al. (2003). Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J Immunol, 170(12), 6209-16.
- Hernández-Rodríguez, J., Segarra, M., Vilardell, C., et al. (2004). Tissue production of pro-inflammatory cytokines (IL-1β, TNFα, and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis. Rheumatology (Oxf.), 43(3), 294-301.
- Southerland, J.H., Taylor, G.W., Moss, K., et al. (2006). Commonality in chronic inflammatory diseases: Periodontitis, diabetes, and coronary artery disease. Periodontology 2000, 40, 130-43.
- Tzouvelekis, A., Pneumatikos, I, Bouros, D. (2005). Serum biomarkers in acute respiratory distress syndrome an ailing prognosticator. Respir Res, 6, 62.
- Miller, C.S., King C.P., Langub, M.C., et al. (2006). Salivary biomarkers of existing periodontal disease: A cross-sectional study. J Am Dent Assoc, 137(3), 322-29.
- Tanda, N., Ohyama, H., Yamakawa, M., et al. (1998). IL-1β and IL-6 in mouse parotid acinar cells: Characterization of synthesis, storage, and release. Am J Physiol, 274(1 Pt1), G147-56.
IL-1β Overview
| Approved Salivary Collection Devices | Serum-Saliva Correlation | Sensitivity | Sample Test Volume | Recommended Collection Volume | Special Considerations | Related Analytes |
|---|---|---|---|---|---|---|
| No | 0.06 pg/mL | 150 μL | 325 μL* | No |
*In addition to the volume recommended for each analyte, we recommend collecting an additional 300 μL to allow for liquid handling loss and possible repeat tests (500 µl recommended for TNF-α and IL-1β).
