The Salimetrics Research Library
Look up current saliva research on
Neopterin
and related analytes here!
Neopterin
Neopterin (D erythro neopterin) belongs to a group of compounds known as pteridines, which are derived from the guanosine triphosphate (GTP), a purine nucleotide. Neopterin is produced by macrophages, and it is a valuable marker of inflammation and of the activation of the cell-mediated (Th1-type) immune system. Neopterin levels are also used as a measure of oxidative stress. Elevated neopterin levels have been associated with infection, cardiovascular disease, autoimmune disease, malignant tumors, psychiatric disorders, sleep-disordered breathing, autistic children, and cognitive decline in Alzheimer’s disease. (1,2) Neopterin is measurable in healthy human saliva, and increased salivary levels have been found in patients with periodontal disease, HIV-1 virus infections, and Sjögren’s Syndrome. (3,4,5) More »
References
- Murr, C., Widner, B., Wirleitner, B., Fuchs, D. (2002). Neopterin as a marker for immune system activation. Curr Drug Metab, 3(2), 175-87.
- Chauhan, A., Chauhan, V. (2006). Oxidative stress in autism. Pathophysiology, 13(3), 171-81.
- Katoh, S., Sueoka, T., Matsuura, S., Sugimoto, T. (1989). Biopterin and neopterin in human saliva. Life Sci, 45(26), 2561-68.
- Reibnegger, G., Fuchs, D., Zangerle, R., Wachter, H. (1990). Increased neopterin concentration in saliva of patients with HIV-1 infection. Clin Chem, 36(7), 1379-80.
- Pradeep, A.R., Kumar, M.S., Ramachandraprasad, M.V., Shikha, C. (2007). Gingival crevicular fluid levels of neopterin in healthy subjects and in patients with different periodontal diseases. J Periodontol, 78(10), 1962-67.
Neopterin Overview
| Approved Salivary Collection Devices | Serum-Saliva Correlation | Sensitivity | Sample Test Volume | Recommended Collection Volume | Special Considerations | Related Analytes |
|---|---|---|---|---|---|---|
| No | 0.51 ng/mL | 50 μL | 125 μL* | No |
*In addition to the volume recommended for each analyte, we recommend collecting an additional 300 μL to allow for liquid handling loss and possible repeat tests (500 µl recommended for TNF-α and IL-1β).
