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Uric Acid Saliva Collection

Approved Collection Methods

Passive Drool

SalivaBio Swabs

Special Considerations

High consumption of alcohol beverages (particularly beer), fructose and diets high in purine-rich foods can alter Uric Acid levels.

Several drugs may alter Uric Acid levels (Moriwaki, 2014) e.g. Antihypercuricemic agents (allopurinol, peglase, febuxostat, rasburicase); Diuretics (loop and thiazide-type); Pyrazinamide and nicotinamide; Lactate; Cyclosporine; Testosterone; Fructose; Xylitol; Theophylline; Cytotoxic; Estrogen; Antihypertensives (Sartans, calcium channel blockers); Fenofibrate; Statins and Salicylic acid

Saliva Collection Protocol

Before Sample Collection

  • Avoid foods with high sugar, acidity, or caffeine immediately before sample collection.
  • Document consumption of alcohol, caffeine, nicotine, and prescription/over-the-counter medications within the prior 12 hours.
  • Document vigorous physical activity and the presence of oral disease, injury or inflammation.
  • Do not brush teeth or eat a major meal within 60 minutes of sample collection.
  • Rinse mouth with water to remove food residue and then wait at least 10 minutes before collecting saliva.

During Sample Collection

  • Recommended Collection Volume: 25 µl*
  • Use a collection device that has been validated for the measurement of this analyte.
  • Follow your selected sample collection device/method protocol.

*Add 300 µl to the total volume of all tests for liquid handling

After Sample Collection

  • Record the time and date of specimen collection.
  • Refrigerate samples immediately (if possible) and freeze at or below -20°C (household freezer) as soon as possible (within 6 hours of sample collection)
  • Samples visibly contaminated with blood should be recollected.
  • Do not add preservatives to saliva samples unless it has been previously validated with the assay.