The Salimetrics cytokine panel measures IL-1β, IL-6, IL-8 & TNF-α concentrations simultaneously using a single, 100 µl saliva sample and features convenient panel pricing. Small sample volumes can be especially beneficial for infant, children, or animal studies and for research where investigators are routinely limited in the amount of saliva that can be collected.
IL-1β, IL-8 and TNF-α are three important examples of a class of signaling molecules known as pro-inflammatory cytokines, which play an important role in initiating the body’s acute phase inflammatory response to infections, injuries, or possibly stress. IL-1β and to a lesser extent TNF-α, have been strongly associated with oral inflammatory conditions including gingivitis and periodontal disease. These conditions play a larger role in more severe systemic diseases such as cardiovascular disease and diabetes. IL-6 also induces the production of C-reactive protein (CRP) in the liver, which when elevated chronically can lead to obesity. Importantly, several reports indicate that all four cytokines may contribute to the pathogenesis of certain oral cancers and have been implicated as markers for early oral cancer detection. Therefore, in addition to their utility in assessing oral inflammation, these markers may also be of interest in other fields, including cancer, asthma, and stress research.
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