DNA: Catechol-O-methyltransferase - COMT

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Genomic DNA, purified using silica based...learn more

Recommended Collection Method

SOS (preferred), SIS, SCS or 500 uL Passive Drool


2-5 ug genomic DNA (?)

Special Considerations

Methods Paper: Assessing genetic polymorphisms using DNA extracted from cells present in saliva samples.

Collection Protocol Download PDF


  1. Grossman, MH. et al. (1992). Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2. Genomics. 12(4), 822-825
  2. Bruder, Ge. et al. (2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biological Psychiatry. 58(11), 901-907.
  3. Robinson, S. et al. (2009). Executive functions in children with autism spectrum disorders. Brain and Cognition. 71(3), 362-368.
  4. Lachman, HM. et al. (1996). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. American Journal of Medical Genetics. 67(5), 468-472.
  5. Chen, J. et al. (2004). Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain. American Journal of Medical Genetics. 75(5), 807-821.
  6. Stein, DJ. et al. (2006). Warriors versus worriers: the role of COMT gene variants. CNS Spectrums. 11(10), 745-748.
  7. Stein, M. et al. (2005). COMT Polymorphisms and Anxiety-Related Personality Traits. Neuropsychopharmacology. 30(2005), 2092-2102.
  8. Kennedy, Q. et al. (2011). The Roles of COMT val158met Status and Aviation Expertise in Flight Simulator Performance and Cognitive Ability. Behavior Genetics. 41(5), 700-708.
  9. Bhakta, SG. et al. (2012). The COMT Met158 allele and violence in schizophrenia: a meta-analysis. Schizophrenia Research. 140(1-3), 192-197.
  10. Soeiro-de-Souza, MG. et al. (2012). COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder. Bipolar Disorders. 14(5), 554-564.

​No, the fluid in the Oragene device will dilute the saliva by an unknown amount and also has the potential to interfere with EIA, thus impeding the accurate measurement of analytes.


​Yes, saliva collected for DNA analysis using SalivaBio or Salimetrics collection devices can be used for other analytes as well. DNA in whole saliva is obtained from the cell pellet after centrifugation.  The supernatant can be used for testing other analytes.  DNA is collected from the actual SalivaBio swabs after centrifugation, so the saliva in the swab storage tube can be used testing other analytes.  Salimetrics recommends collecting the DNA material before testing for other analytes but it still possible to get the DNA sample after testing for other analytes provided that care is taken to prevent cross contamination during the testing phase. See this publication for more information;

Zsofia Nemoda, Maria Horvat-Gordon, Christine K Fortunato, Emilie K Beltzer, Jessica L Scholl and Douglas A Granger;Assessing genetic polymorphisms using DNA extracted from cells present in saliva samples;BMC Medical Research Methodology 2011, 11:170 doi:10.1186/1471-2288-11-170.