*Part of the Salimetrics Cytokine Panel - Not available as an individual test*
Interleukin-8 (IL-8), also known as neutrophil chemotactic factor, belongs to the CXC chemokine family and mainly serves as an immune mediator of neutrophil-dependent acute inflammation (2). IL-8 is produced in various cells and tissues such as phagocytes and mesenchymal cells exposed to inflammatory stimulus, and primarily targets the recruitment and activation of neutrophil granulocytes and other intra-and extracellular changes in response to infection, inflammation, trauma, environmental stress, and steroid hormones, etc. Il-8 has also been suggested to influence T-cell migration. Although neutrophils are the primary target, a variety of other cells also respond to the presence of IL-8.
In serum, IL-8 has shown strong associations with studies in periodontal disease, obesity (3), cancer, oxidative stress (4), rheumatoid arthritis, tumor development and Hepatitis C.