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Fat Mass and Obesity – FTO

Gene Summary
Gene: Fat Mass and Obesity
Gene Symbol: FTO
Related Analyte(s): Insulin, Uric Acid, Cortisol
Common SNPs
rs1421085 , rs1121980 , rs9939609
Assay Methodology
Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system
Yield: 2-5 ug genomic DNA

Collect Saliva Samples

DNA SALIVA COLLECTION CONSIDERATIONS

Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes.

APPROVED SALIVARY DNA COLLECTION METHODS

Test Saliva Samples

@ Salimetrics
Salimetrics SalivaLab - Easy & Accurate
Order Code (lab): 5811 (SNP Genotyping)
Transport Requirements: Ship on Dry Ice
@ Your Own Lab
Salimetrics Assay Kits - Better Results

The validated method used by Salimetrics is proprietary and not available in assay kit form at this time.

References & FTO Related Research

  1. Loos, R. J. F., & Yeo, G. S. H. (2014). The bigger picture of FTO – the first GWAS-identified obesity gene. Nature Reviews. Endocrinology, 10(1), 51–61.
  2. Scuteri, A., et al. (2007). Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLoS Genetics, 3(7), e115.
  3. Saldaña-Alvarez, Y., et al. (2016). Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans. PLoS ONE, 11(1), e0145984.
  4. Willer, C. J., et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics, 41(1), 25–34.
  5. Thorleifsson, G., et al. (2008). Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics, 41(1): 18–24.
  6. Claussnitzer, M., et al. (2015). FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine, 373(10): 895–907.
  7. Hinney, A., et al. (2007). Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants. PLoS ONE, 2(12), e1361.
  8. Karani S., et al (2009). Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. The American Journal of Clinical Nutrition, 90(2): 425–428.